I'm sure you will still be able to find the first one in stores. Although, since I am in the UK, I can't speak for the situation in the States.
The first one will be quite cheap now as it has been around since late 2007.
You don't need to play the first one to play the second. But some of the decisions you make in the first game do affect the second one.
Apart from that ME is one of the best games (IMO) ever produced. So it's worth playing anyway, especially if you like the thought of a Sci-fi RPG.
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