
NASA Ames’ Worden reveals DARPA-funded ‘Hundred Year Starship’ program | KurzweilAI
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But Worden warned that in settling on other worlds, we need to be cautious. “How do you live in another world? I don’t have the slightest idea,” he said. “If you’re a conservative, you worry about it killing us; if you’re a liberal, you worry about us killing it. I think things like synthetic biology have lot of potential for that. I think rather than make an environment on [another world] like Earth, why don’t we modify life … including the human genome … so it’s better suited to [that world]
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Hmmm...

Of course, if there's existing sentient life that's already well suited to that environment, it might be worthwhile to grow special synthetic biological clones that human users can mentally teleoperate. That way the colonists can fully experience the new world and interact with native life. Just a thought...